Membrane traffic control by cytoskeletal and molecular machines

Membrane traffic control by cytoskeletal and molecular machines

Molecular motors and membrane traffic in Dictyostelium.

Phagocytosis and membrane traffic in general are largely dependent on the cytoskeleton and their associated molecular motors. The myosin family of motors, especially the unconventional myosins, interact with the actin cortex to facilitate the internalization of external materials during the early steps of phagocytosis. Members of the kinesin and dynein motor families, which mediate transport al...

Membrane Bound Molecular Machines for Sensing

In this work the construction and dynamic modelling of the Ion Channel Switch (ICS) biosensor is presented. A key feature of the ICS biosensor is that the detection is performed by measuring the timedependent conduction of the engineered tethered membrane which is dependent on the ensemble of aqueous pores and conducting gA dimers present. Using specific molecular components and drive potential...

Molecular machines that control genes.

Molecular Machines in protein targeting and membrane protein biogenesis

1989 Ph.D. Ludwig-Maximilians-Universität München, Germany (Max Planck Institute of Biochemistry, Martinsried) 1989 1991 PostDoc Max Planck Institute for Biophysics, Frankfurt, Germany (Prof. Hartmut Michel) 1991 1993 Scientist Biomedical Centre, Uppsala, Sweden (Prof. Alwyn Jones) 1994 1999 Group Leader European Molecular Biology Laboratory (EMBL), Heidelberg, Structural Biology Programme sinc...